ABSTRACT
Measurement of CEA, CA19-9, and A-FP are tumor markers for colorectal carcinoma, to be used for follow up and to detect early relapse. Specialized Surgical Baghdad -Teaching Hospital. To shade a light on the sensitivity and specificity of these tumor markers [CEA, CA 19-9, and a IT] for colorectal carcinoma. A total of 30 patients with colorectal cancer were studied between June 2003 and April 2004, only 25 were followed up because the remaining 5 were beyond treatment as their CKA level was above 60 ng/ml. so they were excluded. The other patients were studied pie and 3 months post operative!]' as well 20 other non malignant G.I patients and 30 healthy controls. The serum was estimated for CBA, CA19-9, and A-FP by RLFA [Enzyme Linked fluorescent Assay] method. The results show that there is significant difference between scrum level of CCA in pie- operative colorectal cancer patients and control [P<0.0005], and significant difference between the same patients and the post operative group [P<0.05]. While Tor the determination of serum CA 19-9 there arc insignificant differences between the pre- operative group and control, and between the pre- and post- operative groups [P>0.05]. As for the results for a FP There is significant difference between the pre-operative group patients and the non malignant Ci.I patients [P <0.05], and significant difference between the pre- and post- operative groups [P< 0.1]. Significant differences were found in the result of tumor markers [1 A, and a FP studied in patients with colorectal cancer as compared with the other non malignant [I. I patients and control, these results confirm that these markers are good predictors for colorectal cancer. While for CA 19-9 can only be useful in metastasis GIT carcinomas. The sensitivity of using the above mentioned tumor markers together is 84%, while the specificity is 66%
ABSTRACT
The accumulation of the lipid in the vascular smooth muscle cell within the arterial intima is a key process of the pathogenesis of atherosclerosis. Atherosclerosis is a degenerative disease of blood vessels leading to stroke.One hundred and ten patients with acute stroke were included in this study 88 patients with ischaemic or infarction stroke and 22 patients with hemorrhagic type] as well as thirty apparently normal healthy subjects as controls . Triglycerides levels and Al only were statistically significant in ischaemic type of stroke [P<0.005] while other lipid fractions were similar so the control values .Acute stroke patients [infarction type] had significantly elevated TG and low Al. While those with hemorrhagic type had more or less similar lipid profile to normal control. In general the higher the TG level th poorer the outcome in patients with acute stroke